diff --git a/db/db_impl/db_impl.h b/db/db_impl/db_impl.h
index 9c07e81fc..c37a46c3e 100644
--- a/db/db_impl/db_impl.h
+++ b/db/db_impl/db_impl.h
@@ -1187,7 +1187,10 @@ class DBImpl : public DB {
   // WriteToWAL need different synchronization: log_empty_, alive_log_files_,
   // logs_, logfile_number_. Refer to the definition of each variable below for
   // more description.
-  mutable InstrumentedMutex mutex_;
+  //
+  // `mutex_` can be a hot lock in some workloads, so it deserves dedicated
+  // cachelines.
+  mutable CacheAlignedInstrumentedMutex mutex_;
 
   ColumnFamilyHandleImpl* default_cf_handle_;
   InternalStats* default_cf_internal_stats_;
diff --git a/monitoring/instrumented_mutex.h b/monitoring/instrumented_mutex.h
index 1e72815bf..e05c6addd 100644
--- a/monitoring/instrumented_mutex.h
+++ b/monitoring/instrumented_mutex.h
@@ -51,6 +51,14 @@ class InstrumentedMutex {
   int stats_code_;
 };
 
+class ALIGN_AS(CACHE_LINE_SIZE) CacheAlignedInstrumentedMutex
+    : public InstrumentedMutex {
+  using InstrumentedMutex::InstrumentedMutex;
+  char padding[(CACHE_LINE_SIZE - sizeof(InstrumentedMutex) % CACHE_LINE_SIZE) %
+               CACHE_LINE_SIZE] ROCKSDB_FIELD_UNUSED;
+};
+static_assert(sizeof(CacheAlignedInstrumentedMutex) % CACHE_LINE_SIZE == 0);
+
 // RAII wrapper for InstrumentedMutex
 class InstrumentedMutexLock {
  public: